The Premier League chasing Blades snapped up the 17-year-old after his year of rapid progress.
He signs a deal at Bramall Lane until 2021 as Chris Wilder made his move for the National League North club’s teenage striker.
Guiseley’s head of youth Dave Currie said: “Jake is a great example of what can be achieved with hard work and a strong self-belief.
“He came from a Sunday League club and is now a professional football player at a top Championship club.
“Jake is an example to every young player that anything is possible and his move underlines the opportunities available for players at Guiseley AFC Academy.
“We wish him all the very best in the future.”