Should North Ferriby United not win at home to National League North leaders Salford City, then they will become the first side to be relegated this season.
If the pacesetters are successful, Ferriby will be playing Evo-Stik NPL Premier football after collecting just 13 points having gone down from the National League last season.
There’s no doubt Salford can’t afford to have sympathy. They need a win to stretch their lead at the top of the table to five points.
It’s a very big evening at the wrong end of the National League North table.
There’s a huge game down the bottom as Gainsborough Trinity, in 21st, head to FC United - who are just four points outside the drop zone. A home win would claw Tom Greaves’ side right into difficulty and give Trinity great hope of escaping trouble.
At the Impact Arena, two other teams in danger meet as Alfreton Town look to pull away from trouble.
The Reds will take a giant stride towards salvation if they beat AFC Telford United - but the Bucks are third from bottom and are fighting for their lives.
There may not be many play-off places up for grabs with five weeks to go, but one currently belongs to Spennymoor Town. The seventh place club know those just below them will be eyeing it up and they meet one of those teams tonight.
Matt Jansen’s Chorley welcome the Moors and they will put considerable pressure on the promotion places with a home win.
Stockport County will be ready to pounce on dropped points and this evening face a Boston United side still reeling after throwing three points away against FC United on Saturday.
We have one National League game - and it’s a big one for our feature match across social media this evening.
Bromley travel to Solihull Moors with a lot riding on it. The Moors with a decent win will move out of the relegation zone - putting the spotlight firmly on the BT Sport game between Barrow and Hartlepool 24 hours later.
But of course the FA Trophy semi-finalists are chasing the play-offs and one of their games in hand is vital to clawing back the eight points they need to make the top seven.
It’s potentially a big night in the race for the National League South championship.
Havant & Waterlooville go to to Truro City knowing all too well that they face a side who love to knock title chasers off their perch.
Third place Hampton & RB, meanwhile, could potentially close the gap to just two points if things go their way - the Beavers welcome Hungerford Town after drawing at West Leigh Park at the weekend.
St Albans City are back on track, they take on Weston-super-Mare in Somerset. The Seagulls know they must win if they are to force their way into the promotion picture.
Another side who have no other option but to collect three points are Bognor Regis Town - if they don’t beat Welling United at home then the odds on a return to the Isthmian League will shorten.
Especially if fourth-from-bottom Concord Rangers, and 20th place Poole Town, have a good night.
Concord go to Chippenham while Poole travel to Essex to face East Thurrock United.
Make sure you are following us on twitter @TheNationalLge and on instagam for all this evening’s action.