The deal has been agreed with a recall clause and Lowe is not allowed to play against his parent club during his loan spell.
Lowe joined Port from rivals FC United of Manchester in September for an undisclosed fee.
Formerly of the Burnley academy, Rowe scored 9 goals in forty-two appearances for FC United and signed a permanent deal with them in March this year, before scoring a 94th minute 35-yard winner against Tamworth the same day.
Southport manager Kevin Davies told his club`s official website: “Nathan is very much part of our plans. However, he has found it difficult to command a starting berth every week, so we have agreed that regular game time will assist his development, and with that in mind we have agreed to this deal taking place.
“We will be monitoring Nathan during his time at Spennymoor, and have the option to recall him should we feel it necessary”.
(Photo: FC United of Manchester)