Brackley are the league's in-form side and currently occupy third spot.
The Saints head to Southport having dropped just three points in their last ten outings.
Leaders Chorley face a potentially tricky trip to play-off hunters Chester.
Both sides will be all out for the maximum points haul to help their respective causes.
One side watching on anxiously will be Stockport County who know a defeat for the Magpies could open the title door a bit wider.
Jim Gannon's men can only take advantage if the overcome Darlington at Edgeley Park.
The pressure is on for AFC Telford to improve their home form to avoid dropping from the top seven.
Blyth Spartans head to New Bucks Head on the back of a brilliant win at Ashton last time out.
Altrincham currently occupy the play-off place Kidderminster Harriers desire - only a win will do in Greater Manchester for the Harriers.
Another play-off hopeful, Bradford (Park Avenue) host Alfreton Town who have been bang at it in recent weeks.
There's a Yorkshire showdown between Guiseley and York City at Nethermoor Park with the hosts looking to pull away from danger.
Nuneaton Borough will have their fate sealed with anything less than a win at FC United of Manchester.
Hereford should be safe and head to an out of sorts Spennymoor Town looking to put on a show.
Elsewhere, Curzon Ashton make the trip to Lincolnshire to face Boston United while Leamington host struggling Ashton United.
Saturday's National League North fixtures:
AFC Telford United v Blyth Spartans
Altrincham v Kidderminster Harriers
Boston United v Curzon Ashton
Bradford (Park Avenue) v Alfreton Town
Chester v Chorley
FC United of Manchester v Nuneaton Borough
Guiseley v York City
Leamington v Ashton United
Southport v Brackley Town
Spennymoor Town v Hereford
Stockport County v Darlington