Jurgen Klopp will be bringing another strong team for the second consecutive year to face last season's play-off finalists on Wednesday night.
Last summer, Danny Ings' solitary goal handed the five-time European Cup champions the win in front of 13,000 - and tickets are once again selling quickly for this enticing fixture.
Stars such as Dejan Lovren, Joel Matip, Sadio Mané and Roberto Firmino all featured for the Reds in their victory.
Tranmere manager Micky Mellon has added former Liverpool winger Jack Dunn, midfielder Ollie Norburn from Macclesfield Town and most recently striker George Waring to his squad, that's hoping to go one better this season.
"It's fantastic for the club and it will be a huge test for our players," Mellon said. "Hopefully we stand up to the challenge."