The biggest game will undoubtedly come at the AGP Arena where Billericay Town face a huge title six-pointer.
Woking know they can make their game in hand count with a win in Essex but Dean Brennan's men won't go down without a fight.
Steve King isn't phased after back-to-back defeats for his Welling side.
The Wings make the journey to Hemel Hempstead Town looking for a reaction to get their promotion tilt back on track.
Hampton & Richmond Borough were the side to inflict that second defeat and they have a chance to do it all over again.
Torquay United travel to the capital and will be well aware of the threat the Beavers face.
Wealdstone's form has nose-dived in recent weeks. A trip to Truro City could be a chance to re-ignite their season.
Weston-super-Mare reimbursed fans this week who made the trip to Truro City for their FA Trophy hammering.
They'll be hoping for a better outing this weekend against in-form Oxford City.
Eastbourne Borough and St Albans City face-off with both sides needing a win.
It's been a seemingly never-ending run for Gloucester City who can't buy a win at the minute.
Dulwich Hamlet are in town and will be hoping their four-game losing streak ends soon.
Hungerford Town will be aiming to show their rare win last week won't be a flash in the pan.
They travel to Dartford who have tasted defeat in their last two outings.
Concord Rangers will be hoping their two-week lay-off won't have too much of an effect as they host Chippenham Town.
Bath City and Chelmsford City are both still in the hunt for promotion and do battle on Saturday afternoon.
Elsewhere, Slough Town host East Thurrock United.
National League South fixtures:
Bath City v Chelmsford City
Billericay Town v Woking
Concord Rangers v Chippenham Town
Dartford v Hungerford Town
Eastbourne Borough v St Albans City
Gloucester City v Dulwich Hamlet
Hampton & RB v Torquay United
Hemel Hempstead v Welling
Oxford City v Weston-super-Mare
Slough Town v East Thurrock United
Truro City v Wealdstone