Worthing lead the way at the minute with Truro City, Eastbourne Borough, Dorking Wanderers and Torquay United all breathing down their necks.
Further down, Weymouth and Aveley could have their relegation back to Step 3 confirmed depending on how the results pan out.
The Millers will see time called on their two-year stay in the National League South if they lose to Torquay United - results elsewhere would determine their fate if they avoid defeat.
Warren Feeney wants to remain as Weymouth boss whatever happens - the Terras would drop if they lose against Slough and Enfield and Salisbury win.
Both Dorking and Eastbourne have eyes on the summit.
The pair meet at Meadowbank both knowing a win could see them in the driving seat.
Truro City have won seven of their last nine games and head to a Chelmsford City side desperate to add to their one win in their past six games.
Maidstone and Boreham Wood can't end the day top of the pile but both would consider themselves more than in the title race.
Luke Garrard's side have only won once all season against the current top seven while Maidstone are four unbeaten at home.
Worthing have lost two on the spin but will maintain their status as league leaders with a win at home to Hampton & Richmond.
Hornchurch were the Rebels' conquerors midweek - their first win in five games - and have Weston-super-Mare up next who could be in the top seven for the first time in four months.
Welling got their first win since January 7 last week and head to Chesham while Bath City and Hemel Hempstead meet.
St Albans could take another step towards safety with a win over Farnborough but would need a favour from Tonbridge Angels at Salisbury for them to close the gap.
Enfield know a win for them could have them eight points clear of the bottom four - Chippenham Town stand in their way.
National League South fixtures:
Aveley v Torquay United
Bath City v Hemel Hempstead Town
Chelmsford City v Truro City
Chesham United v Welling United
Dorking Wanderers v Eastbourne Borough
Enfield Town v Chippenham Town
Hornchurch v Weston-super-Mare
Maidstone United v Boreham Wood
Salisbury v Tonbridge Angels
St Albans City v Farnborough
Weymouth v Slough Town
Worthing v Hampton & Richmond