Captain Jake Moult has been hit with news he needs surgery on a hernia problem picked up in the latter stages of last season.
With the big kick-off on August 3 just 33 days away, an estimated recovery time of five weeks would mean Moult could miss the first whistle.
Speaking to the club's official website, boss Phil Parkinson doesn't envy the doctor who has to deal with his skipper.
"It was a double hernia, and he will do well to make the opening game," he said. "It's going to be touch and go, but, knowing Jake, he is a very fit lad and he will be a terrible patient.
"The biggest thing for us will be keeping the reins on him and making sure there are no risks taken - but he does hate missing time on the pitch.
"I think it will be five weeks for Jake to be available again," Parkinson added.
"Six weeks is normally the benchmark, but because Jake is so fit and because I know what he is like, I'll be surprised if it's longer than five."
Altrincham will find out their opening day opponents this Wednesday 3 July when next season's fixtures are released.