With the big boys now just one win away, many National League sides will fancy their chances.
There could be an all-National League game with Woking and Tranmere - but both must win tricky replays first.
Maidstone United, who thrashed League Two Cheltenham, make the trip to MK Dons while the FA Cup winners of 2013, Wigan Athletic, travel to AFC Fylde.
Oxford City are the surprise package - they go to Notts County after a fantastic win against Colchester United on Saturday.
Gateshead take on the 2014 Conference champions Luton Town at boast home advantage.
Games will take place on the first week of December with TV ties to be announced in due course.
FA Cup second round draw:
Woking/Bury v Tranmere Rovers/Peterborough
MK Dons v Maidstone United
Newport County v Cambridge United
Wycombe Wanderers v Leatherhead/Billericay
Port Vale v Yeovil Town
Shrewsbury Town v Morecambe
Doncaster Rovers v Northampton/Scunthorpe
Slough Town v Rochdale
AFC Wimbledon v Charlton Athletic
Stevenage v Swindon Town
Mansfield Town v Accrington Stanley/Guiseley
Gateshead v Luton Town
Bradford City v Plymouth Argyle
Blackburn Rovers v Crewe Alexandra
AFC Fylde v Wigan Athletic
Gillingham v Carlisle United
Notts County v Oxford City
Forest Green v Exeter City
Chorley/Fleetwood v Hereford
Coventry City v Boreham Wood