He joins the Vanarama National League South side after a succesful spell at Hungerford Town, writes Tom Feaheny.
He led Town for seven seasons and helped them gain promotion to the league.
Speaking to the club's website after joining Wilkinson said.
“I am incredibly excited to be coming to Wealdstone. Can I say straightaway that this is going to be about togetherness, passion and the future – all things I know the Stones fans are about. I have had a fantastic time at Hungerford but we are coming to Wealdstone to give it our all and I am looking forward to the challenges ahead and to put a smile on faces.
He added: "I know it will take time but we need to make improvements, especially with our home form. We need to see fire and drive and we will work very hard with the lads to do this. I have met some great people at the club already and it is a great honour for me to sign a contract at this club – this is a very happy day for me.
‘May I take this opportunity to pay tribute to Gordon Bartlett who has done such a fantastic job at Wealdstone over so many years. I am really pleased he is staying and I will certainly be seeking his help and advice.
‘I will be holding an open training session this Thursday and I am inviting all fans down to The Vale at 7.30pm to watch and have a chat after”
Wealdstone's first game under their new boss takes place this Saturday against Eastbourne Borough.