AFC Fylde will move top of the North division by avoiding defeat in a tough trip to Alfreton Town.
The Coasters have had a perfect start to the season, winning all four league matches and reaching the FA Cup First Round.
A visit to the Impact Arena could be their biggest test yet, with the Reds buoyant following an undefeated start and 1-0 victory at a strong AFC Telford United outfit at the weekend.
Like Jim Bentley’s side, Southport also find themselves in the play-off places after a positive October.
Saturday’s single goal defeat for Liam Watson’s men is the only league goal they have conceded so far.
Kettering Town will give the division’s meanest defence a cross examination tonight in an intriguing clash at Latimer Park.
Both Farsley Celtic and Leamington are hunting for their first three points of the campaign.
Moving laterally to the South division, capitalising on early games in hand is the aim for four sides at the wrong end of a table still taking shape.
Lee Bircham tasted league victory for the first time with Hemel Hempstead Town on Saturday in a seven-goal thriller at Braintree Town.
The Tudors host a Billericay Town side finding their feet, coming into the match on the back of four straight defeats.
With Dulwich Hamlet and Concord Rangers collecting three points from their opening six games combined, both sides will eye this clash at Champion Hill as a chance to put a first victory on the board.
Tomorrow’s sole league clash sees unbeaten Boston United travel to Bradford (Park Avenue).
In the FA Cup, Stockport County host Chesterfield in a replayed Fourth Qualifying Round fixture, with the winner facing League One Rochdale.
Tonight's Fixtures
Alfreton Town vs AFC Fylde
Dulwich Hamlet vs Concord Rangers
Farsley Celtic vs Leamington
Hemel Hempstead Town vs Billericay Town
Kettering Town vs Southport